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Lara Hooker, Cristine Smoczer, Farhad KhosrowShahian, Marian Wolanski and Michael J. Crawford Microarray-based identification of Pitx3 targets during Xenopus embryogenesis Developmental Dynamics 241

Version of Record online: 9 AUG 2012 | DOI: 10.1002/dvdy.23836

Key findings:

  • A microarray assay and secondary confirmation of Pitx3 morphants indicates that Pax6, β Crystallin-b1 (Crybb1), Hes7.1, and Hes4 are good candidates for direct targets.

  • Four other genes show equivocal promise worthy of consideration: Vent2, and Ripply2 (aka Ledgerline or Stripy), eFGF and RXRα.

  • Novel genes described (but that are likely indirectly affected) are described: Rbp4l, Galectin IX, Baz2b, and Rdh16.

  • In addition to previously described interactions in lens and brain, Pitx3 also intersects the segmentation pathway and retinoid regulation.

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