Marek Pacal and Rod Bremner Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons Developmental Dynamics 241
Article first published online: 13 AUG 2012 | DOI: 10.1002/dvdy.23840
The pan cell cycle markers Pcna, Mcm6, and Ki67 are detectable beyond cell birth in post-mitotic neurons
Ki67 is not extinguished until 10–22 h after final mitosis, coincident with the migration of newborn ganglion and amacrine cells out of the neuroblastic layer.
Timing between cell birth and induction of neuronal markers or disappearance of Ki67 lengthens across development.
Typical G2/M extends from ∼1 h at mouse embryonic day 12.5 to ∼2 h by birth, but in a small fraction of progenitors it is double these lengths.
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