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Marek Pacal and Rod Bremner Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons Developmental Dynamics 241

Article first published online: 13 AUG 2012 | DOI: 10.1002/dvdy.23840

Key findings:

  • The pan cell cycle markers Pcna, Mcm6, and Ki67 are detectable beyond cell birth in post-mitotic neurons

  • Ki67 is not extinguished until 10–22 h after final mitosis, coincident with the migration of newborn ganglion and amacrine cells out of the neuroblastic layer.

  • Timing between cell birth and induction of neuronal markers or disappearance of Ki67 lengthens across development.

  • Typical G2/M extends from ∼1 h at mouse embryonic day 12.5 to ∼2 h by birth, but in a small fraction of progenitors it is double these lengths.

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