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Yi-Hui Chen and John Yu Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos Developmental Dynamics 241

Article first published online: 4 SEP 2012 | DOI: 10.1002/dvdy.23851

Key findings

  • Molecular mechanisms of the developmental defects of parthenogenetic embryos were unraveled.

  • Decreased Sox2+ and Nanog+ epiblast cells but increased Gata4+ primitive endoderm cells were observed in the parthenogenetic inner cell mass.

  • Ectopic Gata4 expression and reduced Elf5 and Tbr2(Eomes) expression were observed in the parthenogenetic trophectoderm.

  • Up-regulation of Fgfr2 phosphorylation leads to increased Gata4 and decreased Nanog expression in parthenotes.

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