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Anabel Herr, Michelle Longworth, Jun-Yuan Ji, Michael Korenjak, David M. MacAlpine and Nicholas J. Dyson Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation Developmental Dynamics 241

Version of Record online: 17 SEP 2012 | DOI: 10.1002/dvdy.23857

Key findings:

  • We have used a list of E2F-regulated genes that has been generated by microarray analysis for a genetic approach to ask which of these targets are important for E2F function in vivo.

  • Our results show that more than half of the genes tested are able to dominantly modify dE2F1-dependent phenotypes, indicating that the expression levels of most dE2F1-regulated genes are rate-limiting for dE2F1 function.

  • We show that the depletion of Orc5 elevates the expression of a dE2F1-regulated gene.

  • Our results reveal the existence of an important feedback mechanism that can elevate dE2F1-dependent transcription in cells where ORC levels are low.

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