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Yongbo Lu, Yucheng Li, Adriana C. Cavender, Suzhen Wang, Alka Mansukhani and Rena N. D'Souza Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling Developmental Dynamics 241

Article first published online: 17 SEP 2012 | DOI: 10.1002/dvdy.23858

Key findings:

  • Twist1 forms heterodimers with ubiquitously expressed E12 and synergistically stimulates Fgfr2 and Fgf10 promoter activities.

  • E12 prevents Twist1 from undergoing lysosomal degradation.

  • Runx2 has no direct effects on Fgfr2 and Fgf10 promoter activities, but it inhibited the stimulatory effects of Twist1 on Fgfr2 promoter.

  • A relative abundance of unbound Twist1, due to Runx2 haploinsufficiency, may lead to elevated FGF signaling, and subsequently the formation of supernumerary teeth in human CCD.

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