Melissa M. Krajcovic and Jonathan S. Minden Assessing the critical period for Rho kinase activity during Drosophila ventral furrow formation Developmental Dynamics 241
Version of Record online: 25 SEP 2012 | DOI: 10.1002/dvdy.23859
Inhibition of Rho kinase by Y-27632 injection before the start of ventral furrow formation (VFF) blocks the completion of VFF, but not the initial steps of VFF.
There is a brief critical period for the requirement of Rho kinase activity, hence myosin II activity, during the concerted apical constriction phase of VFF.
VFF processes outside of this critical period do not require Rho kinase or myosin II activity.
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