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Melissa M. Krajcovic and Jonathan S. Minden Assessing the critical period for Rho kinase activity during Drosophila ventral furrow formation Developmental Dynamics 241

Version of Record online: 25 SEP 2012 | DOI: 10.1002/dvdy.23859

Key findings:

  • Inhibition of Rho kinase by Y-27632 injection before the start of ventral furrow formation (VFF) blocks the completion of VFF, but not the initial steps of VFF.

  • There is a brief critical period for the requirement of Rho kinase activity, hence myosin II activity, during the concerted apical constriction phase of VFF.

  • VFF processes outside of this critical period do not require Rho kinase or myosin II activity.

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