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Dorothy E. Pazin, Laura W. Gamer, Karen A. Cox and Vicki Rosen Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow Developmental Dynamics 241

Version of Record online: 25 SEP 2012 | DOI: 10.1002/dvdy.23861

Key findings:

  • How individual joints acquire unique shapes and specialized structures is unknown.

  • There are fundamental difference in the way joints develop after interzone formation.

  • We use comparative gene expression to identify knee and elbow genes.

  • TGFβ regulates knee development.

  • Muscle development regulates elbow morphogenesis.

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