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Junko Okano, Wataru Kimura, Virginia E. Papaionnou, Naoyuki Miura, Gen Yamada, Kohei Shiota and Yasuo Sakai The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves Developmental Dynamics 241

Version of Record online: 25 SEP 2012 | DOI: 10.1002/dvdy.23862

Key findings

  • CYP26B1 is essential to degrade retinoic acid (RA) in the normal developing palate.

  • Excess RA targets cells in the bend region of palatal shelves, leading to a failure of the horizontal elevation of palatal shelves.

  • The absence of Cyp26b1 results in the suppression of Fgf10, Bmp2, and Tbx1 expression in the bend region of palatal shelves.

  • The deletion of Cyp26b1 also prevents the differentiation of tongue musculature, which affects tongue withdrawal necessary for horizontal elevation of palatal shelves.

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