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Juhee Jeong, Jeffry Cesario, Yangu Zhao, Lorel Burns, Heiner Westphal and John L.R. Rubenstein Cleft palate defect of Dlx1/2−/− mutant mice is caused by lack of vertical outgrowth in the posterior palate Developmental Dynamics 241

Version of Record online: 28 SEP 2012 | DOI: 10.1002/dvdy.23867

Key findings:

  • We investigated the etiology underlying cleft palate of mouse Dlx1/2−/− mutants.

  • The posterior palate failed to grow in these mutants from the onset of palatogenesis.

  • Cell proliferation rate and Cyclin D1 expression were reduced in the mutant posterior palate.

  • Expression of multiple known regulators of palatogenesis was affected in the mutants.

  • We conclude that Dlx1 and Dlx2 are crucial for early stages of palatogenesis.

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