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Wendy Sonnet, Rene Rezsöhazy and Isabelle Donnay Characterization of TALE genes expression during the first lineage segregation in mammalian embryos Developmental Dynamics 241

Version of Record online: 10 OCT 2012 | DOI: 10.1002/dvdy.23873

Key findings:

  • By a systematic approach, we demonstrated the transcription and translation of TALE genes before gastrulation during the first steps of cell differentiation in bovine and in mouse embryos.

  • TALE genes are expressed during the first cell lineage specification in mammals.

  • TALE proteins are present before gastrulation in mammalian morulae and blastocysts.

  • TALE genes expression is differently regulated in mouse and bovine early embryos.

  • TALE mRNA and protein levels are well correlated in early mammalian embryos.

  • TALE proteins are found both in the inner cell mass and trophectoderm cells of mammalian blastocysts.

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