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Marine Grigoryan, Mamdouh H. Kedees, Yelena Guz and Gladys Teitelman Phenotype of entero-endocrine L cells becomes restricted during development Developmental Dynamics 241

Version of Record online: 29 OCT 2012 | DOI: 10.1002/dvdy.23875

Key Findings:

  • The intestine of mouse embryos contains a high number of LK cells, an entero-endocrine cell type that produces the incretins GIP and GLP-1.

  • In contrast to adults, L cells of embryos coexpress glucagon and GLP-1, two hormones that are derived from the glucagon gene by posttranslational processing of the precursor protein proglucagon.

  • Mouse embryonic L cells do not proliferate.

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