Ruth I. Johnson, Sujin Bao and Ross L. Cagan Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog Developmental Dynamics 241
Version of Record online: 29 OCT 2012 | DOI: 10.1002/dvdy.23879
In the Drosophila eye, distribution of the IgCAMs Rst and Hbs is regulated by the adaptor protein Cindr.
Cindr functions in two converse processes, targeting Rst and Hbs for endocytic regulation and stabilizing Rst-Hbs complexes at cell junctions.
Hence, Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85.
Regulation of Cindr is a key step for facilitating tissue plasticity during morphogenesis and maintaining functional structures in mature tissues.
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