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Ruth I. Johnson, Sujin Bao and Ross L. Cagan Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog Developmental Dynamics 241

Article first published online: 29 OCT 2012 | DOI: 10.1002/dvdy.23879

Key Findings:

  • In the Drosophila eye, distribution of the IgCAMs Rst and Hbs is regulated by the adaptor protein Cindr.

  • Cindr functions in two converse processes, targeting Rst and Hbs for endocytic regulation and stabilizing Rst-Hbs complexes at cell junctions.

  • Hence, Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85.

  • Regulation of Cindr is a key step for facilitating tissue plasticity during morphogenesis and maintaining functional structures in mature tissues.

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