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Corinna Singleman and Nathalia G. Holtzman Analysis of postembryonic heart development and maturation in the zebrafish, Danio rerio Developmental Dynamics 241

Article first published online: 5 NOV 2012 | DOI: 10.1002/dvdy.23882

Key findings:

  • A third cardiac rotation, occurring at standard length 3.4 mm (104 hr postfertilization) places the heart in its final orientation.

  • Cardiac maturation significantly modifies cardiac form during larval stages but continues throughout the juvenile stages to adulthood.

  • Ventricle size directly correlates with fish length.

  • Two dominant cardiac trabeculations regulate cardiac form and function.

  • Partial loss of atrial contraction seen in myh6/weahu423/+ results in maintenance of larval cardiac form throughout adulthood.

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