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Rita A. Buresh-Stiemke, Rita L. Malinowski, Kimberly P. Keil, Chad M. Vezina, Arie Oosterhof, Toin H. Van Kuppevelt and Paul C. Marker Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development Developmental Dynamics 241

Article first published online: 5 NOV 2012 | DOI: 10.1002/dvdy.23886

Key findings:

  • Heparan sulfate sulfation modifying enzymes Sulf1 and Hs6st1 have distinct but overlapping expression domains in the developing prostate.

  • BMP4 and BMP7 induced Sulf1 expression in the developing prostate and decreased epithelial HS 6-O sulfation.

  • BMP4 and BMP7 reduced ERK1/2 activation in response to FGF10.

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