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Alex G. Lambi, Talia L. Pankratz, Christina Mundy, Maureen Gannon, Mary F. Barbe, Joan T. Richtsmeier and Steven N. Popoff The Skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis Developmental Dynamics 241

Version of Record online: 5 NOV 2012 | DOI: 10.1002/dvdy.23888

Key findings:

  • Newborn CTGF knockout mice have skeletal site-specific changes in bone formation.

  • Growth plate abnormalities in CTGF KO mice include decreased proliferative zone length and increased hypertrophic zone length.

  • Global and regional differences in CTGF KO skull shape result from allometric (size-based) and nonallometric shape changes.

  • In vivo gene expression from CTGF KO skeletal sites demonstrates contrasting expression patterns; while tibial midshaft shows increased expression of bone formation markers (Runx-2, ALP, OC) and CCN3, parietal bone has decreased expression of bone formation markers and CCN1.

  • Dysregulation of transforming growth factor-β1 (TGF-β1) ligand/receptor gene expression, coupled with unique morphologic aberrations in CTGF KO skulls, points to the TGF-β-CTGF axis as a potential mechanistic explanation for the craniofacial phenotype seen in CTGF KO mice.

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