Alex G. Lambi, Talia L. Pankratz, Christina Mundy, Maureen Gannon, Mary F. Barbe, Joan T. Richtsmeier and Steven N. Popoff The Skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis Developmental Dynamics 241
Version of Record online: 5 NOV 2012 | DOI: 10.1002/dvdy.23888
Newborn CTGF knockout mice have skeletal site-specific changes in bone formation.
Growth plate abnormalities in CTGF KO mice include decreased proliferative zone length and increased hypertrophic zone length.
Global and regional differences in CTGF KO skull shape result from allometric (size-based) and nonallometric shape changes.
In vivo gene expression from CTGF KO skeletal sites demonstrates contrasting expression patterns; while tibial midshaft shows increased expression of bone formation markers (Runx-2, ALP, OC) and CCN3, parietal bone has decreased expression of bone formation markers and CCN1.
Dysregulation of transforming growth factor-β1 (TGF-β1) ligand/receptor gene expression, coupled with unique morphologic aberrations in CTGF KO skulls, points to the TGF-β-CTGF axis as a potential mechanistic explanation for the craniofacial phenotype seen in CTGF KO mice.
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