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Erika Cristina Jorge, Mohi U. Ahmed, Ingo Bothe, Luiz Lehmman Coutinho and Susanne Dietrich RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis Developmental Dynamics 241

Article first published online: 6 NOV 2012 | DOI: 10.1002/dvdy.23889

Key findings:

  • RGMa and RGMb expression patterns in neural tissues are conserved in gnathostome vertebrates.

  • RGMa might be associated with muscle stem cells capable of undertaking myogenesis, and RGMb with cells ready to enter myogenic differentiation.

  • RGMa and RGMb may promote myogenesis by modulating bone morphogenetic signaling and Shh signal transduction.

  • RGM family members may act in maintaining notochord integrity and longitudinal axis formation.

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