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Hai-Lei Ding, David E. Clouthier and Kristin B. Artinger Redundant roles of PRDM family members in zebrafish craniofacial development Developmental Dynamics 242

Version of Record online: 14 NOV 2012 | DOI: 10.1002/dvdy.23895

Key findings:

  • prdm3, 5, 16 are expressed in the zebrafish pharyngeal arches.

  • Knockdown of prdm3 and prdm16 results in neurocranium and viscerocranium defects and, in combination, is additive in the neurocranium.

  • prdm1a with prdm3 or prdm16 Morpholinos together leads to more severe phenotypes.

  • prdm5 mutants have defects in the neurocranium and prdm1a and prdm5 double mutants show more severe phenotypes.

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