David Goldberg, Rajka Borojevic, Monique Anderson, Jason J. Chen, Michael D. Gershon and Elyanne M. Ratcliffe Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut Developmental Dynamics 242
Article first published online: 4 DEC 2012 | DOI: 10.1002/dvdy.23898
Transcripts encoding Robo1 and Robo2 are expressed in developing and adult nodose ganglia.
Transcripts encoding Slit1, Slit2 and Slit3 are expressed in developing and adult gut.
Slit2 protein is located in the outer gut mesenchyme.
Neurites extending from explanted nodose ganglia are repelled by Slit2 in vitro.
Slit/Robo chemorepulsion may contribute to the establishment of the vagal sensory innervation of the fetal gut.
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