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David Goldberg, Rajka Borojevic, Monique Anderson, Jason J. Chen, Michael D. Gershon and Elyanne M. Ratcliffe Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut Developmental Dynamics 242

Article first published online: 4 DEC 2012 | DOI: 10.1002/dvdy.23898

Key Findings:

  • Transcripts encoding Robo1 and Robo2 are expressed in developing and adult nodose ganglia.

  • Transcripts encoding Slit1, Slit2 and Slit3 are expressed in developing and adult gut.

  • Slit2 protein is located in the outer gut mesenchyme.

  • Neurites extending from explanted nodose ganglia are repelled by Slit2 in vitro.

  • Slit/Robo chemorepulsion may contribute to the establishment of the vagal sensory innervation of the fetal gut.

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