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Rishita R. Shah, Anne Koniski, Mansi Shinde, Shelby A. Blythe, Daniel M. Fass, Stephen J. Haggarty, James Palis and Peter S. Klein Regulation of Primitive Hematopoiesis by Class I Histone Deacetylases Developmental Dynamics 242

Version of Record online: 22 JAN 2013 | DOI: 10.1002/dvdy.23906

Key Findings:

  • Class I Histone Deacetylase (HDAC) activity contributes to primitive erythropoiesis in Xenopus and mouse.
  • Exposure to valproic acid or other class I HDAC inhibitors specifically during gastrulation blocks primitive erythropoiesis.
  • HDAC activity contributes to an early step in primitive erythropoiesis.
  • Class I HDACs function downstream of BMP and Gata1.

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