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Simone Lackner, Jamie Schwendinger-Schreck, Dörthe Jülich and Scott A. Holley Segmental Assembly of Fibronectin Matrix Requires rap1b and integrin α5 Developmental Dynamics 242

Article first published online: 7 JAN 2013 | DOI: 10.1002/dvdy.23909

Key Findings:

  • Knockdown of the small GTPase rap1b affects axis extension but not somite border morphogenesis.
  • Knockdown of rap1b in integrin α5/ mutants disrupts somite border morphogenesis along the entire anterior-posterior axis in zebrafish.
  • Loss of somite borders is due to failure of Fibronectin matrix assembly and somite border morphogenesis, not improper segmental patterning.
  • No genetic interaction is observed upon concomitant knockdown of rap1b and ephrinB2a.

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