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Mirco Brondolin, Susanne Berger, Michael Reinke, Hideomi Tanaka, Toshio Ohshima, Bernhard Fuβ and Michael Hoch Identification and Expression Analysis of the Zebrafish Homologs of the ceramide synthase Gene Family Developmental Dynamics 242

Article first published online: 22 JAN 2013 | DOI: 10.1002/dvdy.23913

Key findings:

  • Zebrafish genome hosts nine cers genes which are evolutionarily conserved with respect to the mammalian cers gene family.
  • Cers2, cers3, and cers4 are duplicated in the zebrafish genome, whereas cers1, cers5, and cers6 are present as single copy genes suggesting a sub-functionalization process during evolution.
  • Spatial and temporal expression analysis of zebrafish cers genes during embryogenesis reveals elevated transcript levels in the developing central nervous system.
  • Tissue-specific expression of the various cers homolog genes may indicate a requirement for a broad repertoire of sphingolipids during zebrafish embryogenesis.
  • There is an overlap between cers expression and expression of serine palmitoyl transferase, another key enzyme of de novo ceramide synthesis.

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