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Shoshoni T. Caine and Kelly A. Mclaughlin Regeneration of Functional Pronephric Proximal Tubules After Partial Nephrectomy in Xenopus laevis Developmental Dynamics 242

Article first published online: 28 JAN 2013 | DOI: 10.1002/dvdy.23916

Key Findings:

  • Novel finding that Xenopus laevis pronephric kidneys are capable of regenerating functional proximal tubules within 3 weeks of nephrectomy.
  • Apoptosis occurs within hours of nephrectomy. This event is not a general response to injury, but rather coincides with tubule excision.
  • Xmmp-9 is expressed in a biphasic pattern during the first week after removal of the proximal pronephric tubules. The timing of the first phase of expression is consistent with facilitating the wound healing process, whereas the second phase may be involved in the initial steps of tubule regeneration.

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