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Ling Wu, Borum Sagong, Jae Young Choi, Un-Kyung Kim and Jinwoong Bok A Systematic Survey of Carbonic Anhydrase mRNA Expression During Mammalian Inner Ear Development Developmental Dynamics 242

Version of Record online: 28 JAN 2013 | DOI: 10.1002/dvdy.23917

Key findings:

  • A systematic survey for transcripts of all 16 mammalian carbonic anhydrase isozymes in various organs showed that each organ expresses unique combinations of carbonic anhydrase isozymes.
  • During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes.
  • Each isozyme showed a unique temporal and spatial expression pattern during inner ear development.
  • Expression patterns for some isozymes closely overlapped with genes previously associated with inner ear development or function, such as Pendrin, Pou3f4, or Bmp4.

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