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J. Matthew Velkey and K. Sue O'Shea Expression of Neurogenin 1 in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression Developmental Dynamics 242

Article first published online: 8 FEB 2013 | DOI: 10.1002/dvdy.23920

Key Findings:

  • Inducible expression of Neurogenin1 in ESC provides a novel model of neurogenesis.
  • Pulsed expression of Neurogenin1 produces PNS and CNS neuronal sub-types.
  • Neurog1 promotes differentiation of neuronal precursors that exclusively form neurons.
  • This is the first description of the gene expression cascade downstream of Neurog1.

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