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Erika R. Geisbrecht, Ketki Sawant, Ying Su, Ze (Cindy) Liu, Debra L. Silver, Ashley Burtscher, Xuejiao Wang, Alan Jian Zhu and Jocelyn A. McDonald Genetic Interaction Screens Identify a Role for Hedgehog Signaling in Drosophila Border Cell Migration Developmental Dynamics 242

Version of Record online: 8 FEB 2013 | DOI: 10.1002/dvdy.23926

Key findings:

  • Two independent genetic screens uncover a role for Hh signaling in cell migration.
  • Overexpression of Hh rescues Rac-dependent cell migration defects.
  • Disruption of Hh signaling affects E-cadherin and phosphorylated-tyrosine localization in the migrating border cells.
  • The Rac, Par-1 and Hh signaling pathways intersect in wing vein development.

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