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Chih-Wei Chou, Chih-Hao Chiu and Yi-Wen Liu Fibronectin mediates correct positioning of the interrenal organ in zebrafish Developmental Dynamics 242

Version of Record online: 12 MAR 2013 | DOI: 10.1002/dvdy.23932

Key Findings:

  • Fibronectin accumulates around migrating steroidogenic cells, which are detected by a steroidogenic cell-specific zebrafish transgenic line, during the course of interrenal organ assembly.
  • Migration but not specification of steroidogenic interrenal cells is defective in the zebrafish fibronectin mutant.
  • Fibronectin distribution in the zebrafish interrenal microenvironment is at least in part contributed by the neighboring vasculature.
  • The assembly of zebrafish interrenal organ is aberrant in the absence of Fibronectin, due to migration defects of both steroidogenic and chromaffin cells.

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