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Lucimara Aparecida Sensiate, Débora R. Sobreira, Fernanda Cristina Da Veiga, Denner Jefferson Peterlini, Angelica Vasconcelos Pedrosa, Thaís Rirsch, Paulo Pinto Joazeiro, Frank R. Schubert, Carla Beatriz Collares-Buzato, José Xavier-Neto, Susanne Dietrich and Lúcia Elvira Alvares Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development Developmental Dynamics 243

Version of Record online: 11 MAY 2013 | DOI: 10.1002/dvdy.23948

Key findings

  • Dact1 and Dact2 are dynamically expressed during early chondrogenesis in sites that either overlap or complement Sox9 expression domains.
  • Dact1 and Dact2 are coexpressed in developing joints, tendons, and digit blastemas.
  • Dact1 mRNAs colocalize with nuclear β-catenin protein while Dact2 complements sites of bmpR-1b expression in developing synovial joints of digits.

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