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Carsten Schnatwinkel and Lee Niswander Multiparametric image analysis of lung-branching morphogenesis Developmental Dynamics 242

Version of Record online: 23 APR 2013 | DOI: 10.1002/dvdy.23961

Key Findings

  • Morphologically distinct stages during planar bifurcation and domain branching in lung explants.
  • Lung branching is driven by cell division–based tissue and cell displacement that is coordinated by local mechanical forces.
  • Cell division orientation contributes to tissue morphology. Parallel oriented cell division along the longitudinal epithelial axis favors tissue elongation, whereas perpendicular orientation favors tissue expansion.
  • Myosin light chain kinase is a molecular regulator of bud bifurcation, but not domain branch formation in lung explants.

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