E-mail a Wiley Online Library Link

Jez Huang, Michel Arsenault, Martin Kann, Carlos Lopez-Mendez, Monique Saleh, Dorota Wadowska, Mary Taglienti, Jacqueline Ho, Yuan Miao, David Sims, Jonathan Spears, Alfonso Lopez, Glenda Wright and Sunny Hartwig The transcription factor sry-related HMG box-4 (SOX4) is required for normal renal development in vivo Developmental Dynamics 242

Version of Record online: 29 APR 2013 | DOI: 10.1002/dvdy.23971

Key Findings:

  • SoxC genes exhibit overlapping but distinct patterns of expression in the nephrogenic lineages during renal development.
  • Conditional ablation of Sox4 in the nephrogenic lineage results in reduced nephron number.
  • Postnatal Sox4nephron- mice develop severe early-onset kidney injury leading to renal failure in vivo.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field