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Richard W.D. Gilbert, Matthew K. Vickaryous and Alicia M. Viloria-Petit Characterization of TGFβ signaling during tail regeneration in the leopard Gecko (Eublepharis macularius) Developmental Dynamics 242

Article first published online: 4 JUN 2013 | DOI: 10.1002/dvdy.23977

Key Findings

  • Large induction of phosphorylated SMAD2 in blastema cells indicates robust activation of TGFβ/activin pathway during regeneration.
  • TGFβ1 expression absent in early regenerate tissue and activin-βA mRNA significantly upregulated in regenerate tissue suggestive of dynamic ligand expression patterns.
  • EMT transcription factors Snail1 and Snail2 significantly upregulated in regenerating tissue.

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