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Karolina Mizeracka, Jeffrey M. Trimarchi, Michael B. Stadler and Constance L. Cepko Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling Developmental Dynamics 242

Version of Record online: 2 SEP 2013 | DOI: 10.1002/dvdy.24006

Key findings

  • Profiling of individual Notch1-mutant and wild-type postnatal retinal cells on microarrays reveals changes in gene expression obscured by whole tissue analysis.
  • Notch1-mutant cells down-regulate progenitor and cell cycle markers with a concomitant up-regulation in early rod photoreceptor markers.
  • Based on classification, single Notch1-mutant and wild-type cells represent transition from progenitor to postmitotic cell.
  • Individual wild-type retinal cells express cell type markers of both photoreceptors and interneurons.

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