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Ana Casaca, Ana Cristina Santos and Moisés Mallo Controlling Hox gene expression and activity to build the vertebrate axial skeleton Developmental Dynamics 243

Version of Record online: 29 JUL 2013 | DOI: 10.1002/dvdy.24007

Key Findings

  • Timing of Hox gene activation in the early embryo is essential for proper regulation of vertebral identity.
  • Epigenetic regulation of the Hox clusters is likely to contribute to the temporal control of Hox gene expression in the early embryo.
  • Hox proteins contain patterning information specifying different characteristics of the axial skeleton, which reside to a large extent outside the homeodomain.

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