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Keng Yih Chew, Geoffrey Shaw, Hongshi Yu, Andrew J. Pask and Marilyn B. Renfree Heterochrony in the regulation of the developing marsupial limb Developmental Dynamics 243

Article first published online: 13 NOV 2013 | DOI: 10.1002/dvdy.24062

Key Findings

  • There is high conservation of all genes examined with the mouse and opossum orthologues.
  • The AER in the tammar is more prominent than in the opossum limb.
  • TBX5 expression is only slightly earlier in tammar when compared to the mouse.
  • The faster development of the fore limb compared to that of the hind limb correlates with the early timing of the expression of the key patterning genes in these limbs.

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