Shayna A. Liberman, Rahia Mashoodh, Robert C. Thompson, Dana C. Dolinoy and Frances A. Champagne Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse Ecology and Evolution 2
A major obstacle to studying epigenetics in noninvasive samples is tissue specificity of epigenetic marks. Here, we compare DNA methylation of the NGFI-A (nerve growth factor-inducible protein A) binding site in the promoter of the glucocorticoid receptor (Nr3c1) gene between central (hippocampal) and peripheral noninvasive (fecal) tissues in juvenile Balb/c mice that had received varying levels of postnatal maternal care. Our results indicate that concordance in methylation levels between these tissues within individuals only emerges after accounting for the effects of postnatal maternal care and that maternally induced variation in DNA methylation is limited to the brain.
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