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Niclas Backström, Daria Shipilina, Mozes P. K. Blom and Scott V. Edwards Cis-regulatory sequence variation and association with Mycoplasma load in natural populations of the house finch (Carpodacus mexicanus) Ecology and Evolution 3

Article first published online: 7 FEB 2013 | DOI: 10.1002/ece3.484

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By taking a candidate gene approach, we investigate patterns of genetic variation in cis-regulatory sequences of three genes previously shown to be differentially expressed between populations of house finches naive and historically exposed to the disease Mycoplasma gallisepticum. We show that upstream regions have high GC content, varying genetic variability, and contain several transcription factor-binding sites. We identify two SNPs significantly associated with disease response that are located in cis-regulatory sequences of the gene HSP90a and discuss their potential role in the evolution of resistance in this system.

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