Anna K. Lindholm, Kerstin Musolf, Andrea Weidt and Barbara König Mate choice for genetic compatibility in the house mouse Ecology and Evolution 3
In wild house mice, a selfish genetic element called the t haplotype showed 90% drive and caused a 40% reduction in litter size through prenatal mortality in heterozygote crosses. Heterozygous females reduced the occurrence of such genetically incompatible fertilizations by preferring wild-type males in a free-living population, and through a fertilization bias in favor of + sperm in monogamous matings with heterozygote males in the laboratory. The mechanism underlying the apparent ability to discriminate between + and t is consistent with recognition of the unique MHC haplotype that we found to be linked to the t.
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