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Joseph Park, Doyeon Bang, Eunjung Kim, Jaemoon Yang, Eun-Kyung Lim, Jihye Choi, Byunghoon Kang, Jin-Suck Suh, Hyo Seon Park, Yong-Min Huh and Seungjoo Haam Effect of Ligand Structure on MnO Nanoparticles for Enhanced T1 Magnetic Resonance Imaging of Inflammatory Macrophages European Journal of Inorganic Chemistry 2012

Version of Record online: 30 OCT 2012 | DOI: 10.1002/ejic.201201026

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Carboxymethyl-dextran can replace the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. The modification to the dextran converts the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages.

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