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Annalisa Dean, Éva Sija, Éva Zsigó, Maria Grazia Ferlin, Daniele Marton, Valentina Gandin, Cristina Marzano, Denis Badocco, Paolo Pastore, Alfonso Venzo, Roberta Bertani, Tamás Kiss and Valerio Di Marco Possible Chelating Agents for Iron and Aluminium – 4-Hydroxy-5-methyl- and 4-Hydroxy-1,5-dimethyl-3-pyridinecarboxylic Acid European Journal of Inorganic Chemistry 2013

Article first published online: 23 JAN 2013 | DOI: 10.1002/ejic.201201040

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4-Hydroxy-5-methyl-3-pyridinecarboxylic acid (DQ5) and 4-hydroxy-1,5-dimethyl-3-pyridinecarboxylic acid (DQ715) were evaluated for Fe and Al chelation therapy. Metal/ligand solution chemistry, electrochemistry, cytotoxicity and chelation efficiency in vitro were studied. DQ715 is a chelator for both metal ions, whereas DQ5 is more suitable as a selective Al chelator.

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