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Fabio Arnesano, Maurizio Losacco and Giovanni Natile An Updated View of Cisplatin Transport European Journal of Inorganic Chemistry 2013

Version of Record online: 27 MAR 2013 | DOI: 10.1002/ejic.201300001

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Membrane transporters and soluble chaperones of copper ions mediate cellular uptake of and resistance to platinum-based drugs. In this microreview, the interactions of cisplatin with the methionine-rich motifs of the copper permease Ctr1 and with the cysteine motifs of the cytosolic copper chaperone Atox1 are described. Only in the latter case does the drug retain its ammine ligands essential for antitumor activity.

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