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Francesca Di Sarra, Barbara Fresch, Riccardo Bini, Giacomo Saielli and Alessandro Bagno Reactivity of Auranofin with Selenols and Thiols – Implications for the Anticancer Activity of Gold(I) Compounds European Journal of Inorganic Chemistry 2013

Article first published online: 2 APR 2013 | DOI: 10.1002/ejic.201300058

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The reactivity of the drug auranofin, a gold(I) complex with anticancer properties, towards selenols and thiols is investigated by multinuclear NMR spectroscopy and DFT calculations. Useful insights that are relevant to the mechanism of inhibition of thioredoxin reductase are obtained.

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