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Benoît Bertrand, Andreia de Almeida, Evelien P. M. van der Burgt, Michel Picquet, Anna Citta, Alessandra Folda, Maria Pia Rigobello, Pierre Le Gendre, Ewen Bodio and Angela Casini New Gold(I) Organometallic Compounds with Biological Activity in Cancer Cells European Journal of Inorganic Chemistry

Article first published online: 13 MAY 2014 | DOI: 10.1002/ejic.201402248

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Organometallic N-heterocyclic carbene gold(I) complexes bearing a fluorescent coumarin ligand are synthesized, and their antiproliferative effects in normal and tumor cells in vitro are studied. Their biological properties may be due to inhibition of thioredoxin reductases. Fluorescence confocal microscopy allows the uptake of the compounds in cancer cells to be observed.

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