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John L. Harwood, Umi S. Ramli, Mingguo Tang, Patti A Quant, Randall J. Weselake, Tony Fawcett and Irina A. Guschina Regulation and enhancement of lipid accumulation in oil crops: The use of metabolic control analysis for informed genetic manipulation European Journal of Lipid Science and Technology 115

Version of Record online: 2 SEP 2013 | DOI: 10.1002/ejlt.201300257

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A simplified lipid biosynthesis scheme as used in our metabolic control analysis. Carbon flux from [1-14C]acetate enters Block A to produce fatty acids. Block A contains a number of enzymes involved in [1-14C]acetate metabolism. The cytosolic acyl-CoA pool is the defined system intermediate and its level could be increased with exogenous oleate in single-manipulation experiments. In contrast with radioactivity from [1-14C]acetate, which enters Block B reactions (Kennedy pathway conversions and other reactions for lipid synthesis) via the acyl-CoA pool, [U-14C]glycerol labeled acyl lipids via the Kennedy pathway reactions directly.

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