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Panchami Prabhakaran, Anna Barnard, Natasha S. Murphy, Colin A. Kilner, Thomas A. Edwards and Andrew J. Wilson Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α-Helix-Mediated p53–hDM2 Protein–Protein Interaction European Journal of Organic Chemistry 2013

Article first published online: 8 MAY 2013 | DOI: 10.1002/ejoc.201300069

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A 3-O-alkylated aromatic oligoamide foldamer incorporating an additional and hydrophilic 6-O-alkyl substituent in the central monomer is shown to have improved solubility, adopt an active binding conformation and disrupt the p53–hDM2 interaction.

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