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Liana R Stein and Shin-ichiro Imai Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging The EMBO Journal 33

Version of Record online: 8 MAY 2014 | DOI: 10.1002/embj.201386917

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NAD+ and the NAD+ biosynthetic enzyme Nampt decline in the aging hippocampus. Nampt ablation in adult neural stem cells in vivo reduces cell numbers, proliferation, and oligodendrogenesis. Decreases in the stem cell pool are reversed by enhancing hippocampal NAD+.

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