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Taro Chaya, Yoshihiro Omori, Ryusuke Kuwahara and Takahisa Furukawa ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport The EMBO Journal 33

Article first published online: 5 MAY 2014 | DOI: 10.1002/embj.201488175

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Intestinal cell kinase (ICK) phosphorylates the kinesin-2 subunit Kif3a to regulate intraflagellar transport and therefore ciliary morphogenesis. ICK deficiency leads to cell type-specific loss of cilia and defective Sonic Hedgehog signaling during central nervous system development.

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