Ulrike Begley, Maria Soledad Sosa, Alvaro Avivar-Valderas, Ashish Patil, Lauren Endres, Yeriel Estrada, Clement T.Y. Chan, Dan Su, Peter C. Dedon, Julio A. Aguirre-Ghiso and Thomas Begley A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α EMBO Molecular Medicine 5
Article first published online: 4 FEB 2013 | DOI: 10.1002/emmm.201201161
The human tRNA methyltransferase 9-like (hTRM9L) gene is turned off in many cancers and hTRM9- deficient cells are susceptible to killing by aminoglycoside antibiotics, suggesting that these drugs could be re-purposed to treat late stage cancers.
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