Verena Labi, Daniela Bertele, Claudia Woess, Denise Tischner, Florian J. Bock, Sven Schwemmers, Heike L. Pahl, Stephan Geley, Mirjam Kunze, Charlotte M. Niemeyer, Andreas Villunger and Miriam Erlacher Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf EMBO Molecular Medicine 5
Article first published online: 24 NOV 2012 | DOI: 10.1002/emmm.201201235
Many haematological diseases can only be cured by blood stem cell transplantation. The authors show that apoptosis inhibition at the level of Bcl-2 proteins leads to an extended life span of blood stem cells and facilitates engraftment in vivo.
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