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Sahar A. Saddoughi, Salih Gencer, Yuri K. Peterson, Katherine E. Ward, Archana Mukhopadhyay, Joshua Oaks, Jacek Bielawski, Zdzislaw M. Szulc, Raquela J. Thomas, Shanmugam P. Selvam, Can E. Senkal, Elizabeth Garrett-Mayer, Ryan M. De Palma, Dzmitry Fedarovich, Angen Liu, Amyn A. Habib, Robert V. Stahelin, Danilo Perrotti and Besim Ogretmen Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis EMBO Molecular Medicine 5

Version of Record online: 25 NOV 2012 | DOI: 10.1002/emmm.201201283

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The authors show that targeting I2PP2A/SET by FTY720 suppresses lung tumour growth via PP2A-dependent RIPK1 activation leading to necroptosis.

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