Yan Liu, Oriana E. Hawkins, Yingjun Su, Anna E. Vilgelm, Tammy Sobolik, Yee-Mon Thu, Sara Kantrow, Ryan C. Splittgerber, Sarah Short, Katayoun I. Amiri, Jeffery A. Ecsedy, Jeffery A. Sosman, Mark C. Kelley and Ann Richmond Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence EMBO Molecular Medicine 5
Article first published online: 25 NOV 2012 | DOI: 10.1002/emmm.201201378
The authors suggest that aurora kinase inhibitors may effectively slow tumour growth via senescence to provide effective therapy for certain melanoma patients.
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